Flathead catfish are Ohio’s largest river predator, growing to 50+ pounds in the Ohio River and Muskingum River systems. Unlike channel cats, flatheads strongly prefer live bait. They’re nocturnal feeders that become most active after dark during hot summer months.
Regulations shown are statewide defaults. Some waters have special regulations — always check the
current Ohio DNR regulations
before fishing. An Ohio fishing license is required for ages 16+.